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. 2015 Mar;148(2):82–89. doi: 10.1177/1715163515570111

Table 2.

Drugs of choice in penicillin or cephalosporin-allergic patients2,5,11,20,21

  • Patients with a history of a severe allergic reaction to penicillin or any allergic reaction to cephalosporins should receive an alternate therapy for gonorrhea that does not include either of these drug classes.

  • Azithromycin monotherapy is only recommended in cases of contraindications to cephalosporins (e.g., severe allergy) due to risk of possible treatment failure in settings of emerging resistance.

  • Test of cure is required following treatment.

Choices include:

  • Spectinomycin 2 g IM plus azithromycin 1 g PO each as a single dose


or

  • Azithromycin 2 g PO as a single dose