Agent	Effects
Asparaginase	Hypersensitivity reactions, pancreatitis, thrombosis
Clofarabine	Cardiotoxicity, cytokine release syndrome, hepatotoxicity (including sinusoidal obstruction syndrome), pancreatitis, nephrotoxicity
Corticosteroids	Hypertension, hyperglycemia, osteonecrosis, fluid retention, psychosis
Cyclophosphamide	Nephrotoxicity, hemorrhagic cystitis, hyponatremia, fluid retention
Cytarabine	Conjunctivitis, flu-like symptoms
Doxorubicin/daunorubicin	Cardiotoxicity, benign red urine
Etoposide	Nephrotoxicity, hepatotoxicity, hypersensitivity reactions
Mercaptopurine	Hepatotoxicity
Methotrexate	Mucositis, nephrotoxicity, hepatotoxicity, encephalopathy
Thioguanine	Hepatotoxicity (including sinusoidal obstruction syndrome and portal hypertension)
Vincristine	Syndrome of inappropriate diuretic hormone, neuropathy (foot/wrist drop, paresthesias, constipation, ptosis, vocal cord paresis)