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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: J Long Term Eff Med Implants. 2014;24(4):283–296. doi: 10.1615/jlongtermeffmedimplants.2014010564

FIG. 4.

FIG. 4

Toll-like receptors (TLRs) in aseptic interface tissue. (a) Interface tissue macrophages and foreign body giant cells express a spectrum of TLRs including TLR1, TLR2, TLR4, and TLR6 as evaluated by immunohistochemical staining. (b) The relative expression of several TLRs including TLR1, TLR2, TLR4, and TLR6 is significantly increased in aseptic interface tissue compared to osteoarthritic synovial tissue as evaluated by qRT PCR. (*) p < 0.05; (**) p < 0.01; (***) p < 0.001 as evaluated using Mann-Whitney U test. Data from Ref. 55.