Table 3b. Comparison at different thresholds between clinical and combined grades.

Cutoff	κ	Sensitivity	CI	Specificity	CI	LR+	CI	LR−	CI
Proliferative vs nonprolif	0.858	0.85	0.79–0.90	0.99	0.99–0.99	91.11	56.51–146.90	0.15	0.1–0.22
Non-STDR vs sight-threatening DR	0.746	0.75	0.72–0.78	0.97	0.96–0.98	24.89	17.92–34.58	0.25	0.23–0.29
CSMO vs no CSMO	0.623	0.78	0.72–0.83	0.94	0.93–0.95	13.30	10.95–16.15	0.23	0.18–0.30
Any maculopathy vs no maculopathy	0.679	0.88	0.85–0.91	0.86	0.85–0.88	6.45	5.67–7.33	0.14	0.11–0.17

Abbreviations: CI, confidence interval; LR+ and LR−, positive and negative likelihood ratios.

N=1964 for retinopathy; N=2110 for maculopathy.