Table 2. Serology, nasal wash and tissue titres in virus re-challenged ferrets.
# | Group | Site of infection | HAI titer | MN titer | Re-challenge virus |
Titres post challenge* |
|||
---|---|---|---|---|---|---|---|---|---|
Nasal wash | Nasal† | Trachea† | Lung† | ||||||
1 | Naive | NA | 0 | 0‡ | rgCA/09 | 105.25 § | 105.25 | 103.5 | 104 |
0|| | 104 ¶ | ||||||||
2 | Naive | NA | 0 | 0 | CA/09-PA NLuc | 105.5 | 105.5 | 103.5 | 103.75 |
0 | 103.5 | ||||||||
3 | Donor 1 | Nasal and lung | 1,280 | 1:1,600 | CA/09-PA NLuc | 0 | 0 | 0 | 0 |
1:12,800 | 0 | ||||||||
4 | Direct contact 3 | Nasal and lung | 320 | 1:200 | CA/09-PA NLuc | 0 | 0 | 0 | 0 |
1:2,400 | 0 | ||||||||
5 | Direct contact 2 | Lung only | 320 | 1:100 | CA/09-PA NLuc | 104.5 | 103.75 | 101 | 102.5 |
1:1,600 | 102.5 |
NA, not applicable.
*TCID50 per ml.
†Three days post challenge only.
‡Enzyme-linked immunosorbent assay end point.
§One day post challenge.
||Luminescent end point.
¶Three days post challenge.