Table 1. Independent SNPs with MAF≥1% associated with serum TSH and FT4 levels in the overall meta-analysis.

Gene	SNP	Chromosome	Position	A1/A2	Freq A1	Effect	Std Err	N	P	Het P
TSH
CAPZB	rs12410532	1	19845279	T/C	0.164	−0.090	0.016	16,332	9.41 × 10−9	0.003
IGFBP2	rs7568039	2	217612321	A/C	0.250	−0.122	0.014	16,335	2.11 × 10−19	0.370
SYN2	rs310763	3	12230704	T/C	0.235	0.083	0.014	16,334	6.15 × 10−9	0.252
NR3C2	rs28435578	4	149646538	C/T	0.227	−0.166	0.014	16,333	4.59 × 10−32	0.109
PDE8B	rs2046045	5	76535811	G/T	0.414	0.142	0.012	16,334	4.05 × 10−33	0.653
PDE8B	rs2928167	5	76477820	G/A	0.104	−0.145	0.019	16334	5.94 × 10−14	0.994
VEGFA	rs6923866	6	43901184	C/T	0.280	−0.102	0.013	16,333	7.55 × 10−15	0.646
VEGFA	rs2396084	6	43804825	A/G	0.287	−0.096	0.013	16,333	4.33 × 10−13	0.422
PDE10A	rs3008034	6	166043862	C/T	0.312	−0.131	0.012	16,335	4.68 × 10−26	0.084
FOXE1	rs112817873	9	100548934	T/A	0.323	−0.140	0.015	11,544	6.15 × 10−20	2.02 × 10−6
ABO	rs116552240	9	136149098	A/T	0.239	0.121	0.016	14,047	1.92 × 10−14	4.11 × 10−4
MBIP	rs116909374	14	36738361	T/C	0.043	−0.208	0.032	15,037	4.69 × 10−11	0.179
MAF	rs17767742	16	79740541	G/C	0.354	−0.113	0.012	16,335	5.64 × 10−20	0.447
FT4
DIO1	rs2235544	1	54375570	A/C	0.499	0.154	0.013	13,650	5.23 × 10−34	0.084
AADAT	rs7694879	4	170969799	T/C	0.095	0.137	0.022	13,650	4.15 × 10−10	0.168
LHX3	rs11103377	9	139097135	G/A	0.496	0.087	0.013	13,651	1.44 × 10−11	0.735
B4GALT6	rs113107469	18	29306737	T/C	0.032	0.223	0.037	13,649	1.27 × 10−9	0.574

FT4, free thyroxine; MAF, minor allele frequency; SNP, single nucleotide polymorphism; TSH, thyrotropin.

Table shows the association results for SNPs that reached genome-wide level significance in the final meta-analysis. For each SNP, the best candidate gene is showed, as well as its genomic position, the effect allele (A1), the other allele (A2), the combined frequency of A1 across studies (Freq A1) the effect size (beta—change in standardized thyroid measure by allele) and its standard error (Std Err), the P value for association (P), the number of samples analysed (N) and the P values for heterogeneity of effects across the cohorts used in the meta-analysis (Het P). Entries in bold reflect novel identified SNPs.