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. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356

Figure 1. β3-AR agonism reduces body fat mass in E3L.CETP mice.

Figure 1

(a) Body weight, (b) gain of total body fat mass, (c) lean mass and (d) cumulative food intake were determined in WTD-fed E3L.CETP mice at the indicated time points during treatment with the β3-AR agonist CL316243 or vehicle. (e) After necropsy at week 10, the weight of various organs was determined. (f) Epididymal WAT (epiWAT) was stained with haematoxylin–eosin (HE) and representative pictures are shown. Scale bar, 100 μm. (g) Lipid droplet size of white adipocytes was quantified. visWAT, visceral WAT; scWAT, subcutaneous WAT; intBAT, interscapular brown adipose tissue; subBAT, subscapular BAT; pVAT, perivascular adipose tissue. Values are means±s.e.m. (a–e: n=13–19 per group; f,g: n=8 per group). *P<0.05, **P<0.01, ***P<0.001 (unpaired two-tailed Student’s t-test).