Table 3.
Studies of Ewing sarcoma conducted in the USA
| Study | Author | No. of patients | Chemotherapy | 5-year relapse-free survival (%) |
|---|---|---|---|---|
| IESS-I | Nesbit et al. [8] | 331 | VAC | 24 |
| VAC + whole lung RT | 44 | |||
| VACD | 60 | |||
| IESS-II | Burgert et al. [9] | 293 | VACD (intensified) | 68 |
| VACD (moderate) | 48 | |||
| NCI INT-0091 | Grier et al. [10] | 200 | VDC | 54 |
| 198 | VDC + IE | 69 | ||
| COG AEWS0031 | Womer et al. [11] | 587 | VDC + IE 3-week interval | 65 (5 year-EFS) |
| VDC + IE 2-week interval | 73 (5 year-EFS) |
VAC: VCR + ACT-D + CPM
VACD: VAC + DOX
VDC: VCR + DOX + CPM
IE: IFO + ETO