Table 2.
Summary Statistics for Pharmacokinetic Measures in Children Following an Oral Moxifloxacin Dose of 10 mg/kg
| Pharmacokinetic Measure | No. | Moxifloxacin |
|---|---|---|
| Cmax, µg/mL | 23 | 3.08 (2.85–3.82) |
| Tmax, h | 23 | 2.0 (1.0–8.0) |
| CL/F, L/h | 12 | 10.53 (7.23–14.14) |
| Vd, L | 12 | 70.61 (57.53–77.70) |
| C0, µg/mL | 12 | 4.27 (3.38–4.86) |
| T1/2, h | 12 | 4.14 (3.45–6.11) |
| AUC0–8, µg × h/mL | 23 | 17.24 (14.47–21.99) |
| AUC0–24, µg × h/mL | 12 | 23.31 (19.24–42.30) |
All pharmacokinetic measures are reported as median and interquartile range, except for Tmax, which is reported as median and range.
Abbreviations: AUC0–8, area under the curve from 0–8 hours; AUC0–24, area under the curve from 0–24 hours; C0, concentration at time 0; CL, clearance; Cmax, maximum serum concentration; F, fraction absorbed; T1/2, half-life; Tmax, time until Cmax; Vd, volume of distribution.