Table 1.

Clinical and Laboratory Features

Patient No.	Age/Sex/Ethnicity	Anti–GM-CSF Autoantibody Status	Nocardia Speciation and Sites	Other Infections	Comorbidities/ Other Autoimmunity	Absolute CD4 Count	Absolute Neutrophil Count	DHR Analysis	IgG Level	Follow- up	Comments
1	44/M/US white	Positive	N. paucivorans (brain)	None	None	849 cells/µL	2840 cells/µL	Normal	483 mg/dL	Resolved; Stable on TMP-SMX prophylaxis
2	73/M/white Portuguese	Positive	Nocardia unspeciated (cutaneous)	Pulmonary aspergillosis	None	221 cells/µL	8870 cells/µL	Not done	2240 mg/dL	Stable on TMP-SMX, AMC, and GM-CSF
3	61/M/US white	Positive	N. farcinica (brain)	None	None	397 cells/µL	4770 cells/µL	Normal	704 mg/dL	Stable on TMP-SMX, MXF, and GM-CSF
4	50/M/US white	Positive	N. paucivorans (brain)	None	None	707 cells/µL	1900 cells/µL	Normal	818 mg/dL	Complete recovery after 12 mo antibiotic therapy. Off antibiotics for >1 y	Previously reported [19]
5	52/F/African American	Positive	N. asteroides (lung, brain)	Disseminated cryptococcosis	Type II diabetes mellitus (hemoglobin A1C 8.6%), prior necrotizing pancreatitis	403 cells/µL	3190 cells/µL	Not done	965 mg/dL	Off antibiotics, no signs of PAP to date	Previously reported [20]
6	18/M/US white	Negative	N. transvalensis (CNS)	None	Developed panhypopituitarism from infection	726 cells/µL	2900 cells/µL	Normal	424 mg/dL	Resolved	Previously reported [21]; mild hypo- gammaglobulinemia likely steroid induced
7	54/F/US white	Negative	N. beijingensis (lung, presumed CNS)	Chronic pulmonary infections: MAC, Aspergillus, Stenotrophomonas, Serratia	Bronchiectasis	842 cells/µL	2110 cells/µL	Normal	1160 mg/dL	Unknown

Abbreviations: AMC, amoxicillin/clavulanate; CNS, central nervous system; DHR, dihydrorhodamine; GM-CSF, granulocyte macrophage colony-stimulating factor; IgG, immunoglobulin G; MAC, Mycobacterium avium complex; MXF, moxifloxacin; PAP, pulmonary alveolar proteinosis; TMP-SMX, trimethoprim-sulfamethoxazole.