Table 3.
Summary of the results of the gene-enrichment analyses
| Database | Term | Count | P-value | Fold enrichment | Bonferroni 5% |
|---|---|---|---|---|---|
| GOTERM_BP_FAT | GO:0051249∼regulation of lymphocyte activation | 24 | 1.6E−11 | 5.85 | 3.6E−08 |
| GOTERM_BP_FAT | GO:0002694∼regulation of leukocyte activation | 25 | 2.9E−11 | 5.43 | 6.2E−08 |
| GOTERM_BP_FAT | GO:0046649∼lymphocyte activation | 27 | 4.3E−11 | 4.89 | 9.4E−08 |
| GOTERM_BP_FAT | GO:0050865∼regulation of cell activation | 25 | 8.9E−11 | 5.15 | 1.9E−07 |
| GOTERM_BP_FAT | GO:0045321∼leukocyte activation | 28 | 6.9E−10 | 4.17 | 1.5E−06 |
| GOTERM_BP_FAT | GO:0050670∼regulation of lymphocyte proliferation | 17 | 8.1E−10 | 7.39 | 1.8E−06 |
| GOTERM_BP_FAT | GO:0070663∼regulation of leukocyte proliferation | 17 | 9.7E−10 | 7.30 | 2.1E−06 |
| GOTERM_BP_FAT | GO:0032944∼regulation of mononuclear cell proliferation | 17 | 9.7E−10 | 7.30 | 2.1E−06 |
| GOTERM_BP_FAT | GO:0050671∼positive regulation of lymphocyte proliferation | 14 | 2.3E−09 | 9.18 | 4.9E−06 |
| GOTERM_BP_FAT | GO:0032946∼positive regulation of mononuclear cell proliferation | 14 | 2.9E−09 | 9.02 | 6.3E−06 |
| GOTERM_BP_FAT | GO:0070665∼positive regulation of leukocyte proliferation | 14 | 2.9E−09 | 9.02 | 6.3E−06 |
| GOTERM_BP_FAT | GO:0030098∼lymphocyte differentiation | 18 | 2.9E−09 | 6.30 | 6.4E−06 |
| GOTERM_BP_FAT | GO:0050863∼regulation of T cell activation | 19 | 3.2E−09 | 5.86 | 7.0E−06 |
| GOTERM_BP_FAT | GO:0001775∼cell activation | 29 | 7.0E−09 | 3.65 | 1.5E−05 |
| GOTERM_BP_FAT | GO:0051251∼positive regulation of lymphocyte activation | 17 | 8.7E−09 | 6.32 | 1.9E−05 |
| SP_PIR_KEYWORDS | B-cell | 8 | 1.2E−08 | 23.53 | 4.6E−06 |
| GOTERM_BP_FAT | GO:0002521∼leukocyte differentiation | 19 | 2.0E−08 | 5.23 | 4.4E−05 |
| GOTERM_BP_FAT | GO:0002696∼positive regulation of leukocyte activation | 17 | 3.2E−08 | 5.79 | 7.0E−05 |
| GOTERM_BP_FAT | GO:0030888∼regulation of B cell proliferation | 10 | 3.7E−08 | 12.88 | 8.1E−05 |
| GOTERM_BP_FAT | GO:0002684∼positive regulation of immune system process | 25 | 4.5E−08 | 3.79 | 9.9E−05 |
| GOTERM_BP_FAT | GO:0050867∼positive regulation of cell activation | 17 | 6.3E−08 | 5.52 | 1.4E−04 |
| GOTERM_BP_FAT | GO:0050864∼regulation of B cell activation | 12 | 1.1E−07 | 8.49 | 2.4E−04 |
| GOTERM_BP_FAT | GO:0050870∼positive regulation of T cell activation | 14 | 1.4E−07 | 6.65 | 3.1E−04 |
| GOTERM_BP_FAT | GO:0002520∼immune system development | 26 | 1.9E−07 | 3.40 | 4.2E−04 |
| INTERPRO | IPR011993:Pleckstrin homology-type | 27 | 2.1E−07 | 3.30 | 1.7E−04 |
| GOTERM_BP_FAT | GO:0048534∼hemopoietic or lymphoid organ development | 25 | 2.4E−07 | 3.47 | 5.3E−04 |
| GOTERM_BP_FAT | GO:0042110∼T cell activation | 17 | 3.8E−07 | 4.87 | 8.2E−04 |
| INTERPRO | IPR001849:Pleckstrin homology | 25 | 5.3E−07 | 3.34 | 4.1E−04 |
| KEGG_PATHWAY | hsa05340:Primary immunodeficiency | 9 | 4.0E−06 | 9.08 | 4.6E−04 |
| KEGG_PATHWAY | hsa04662:B cell receptor signaling pathway | 12 | 6.2E−06 | 5.65 | 7.1E−04 |
| GOTERM_BP_FAT | GO:0051249∼regulation of lymphocyte activation | 24 | 1.6E−11 | 5.85 | 3.6E−08 |
| GOTERM_BP_FAT | GO:0002694∼regulation of leukocyte activation | 25 | 2.9E−11 | 5.43 | 6.2E−08 |
Pathways found significantly enriched are reported on the basis of their Bonferroni 5% adjusted P-values. Gene-enrichment analyses are based on the 745 CLL-specific candidates found for the full population.