Table 5.
Frequency of Minor Allele of Each Tagging SNP of RPS6KA1 on Chromosome 1p36.11 in Long-Lived Case vs Control Participants
| SNP ID | Position | Total Number of Cases and Controls | Minor Allele Frequency of Cases and Controls, % (95% CI) | χ2 | p Value |
|---|---|---|---|---|---|
| rs12094989 | 26720973 | 184/358 | 27.2 and 30.0 (–0.084 to 0.029) | 1.72 | .42 |
| rs17162190 | 26745419 | 177/346 | 27.4 and 31.4 (–0.097 to 0.019) | 1.70 | .42 |
| rs2278978 | 26745832 | 183/355 | 23.0 and 24.9 (–0.073 to 0.034) | 3.10 | .22 |
| rs4970510 | 26783341 | 180/346 | 13.6 and 14.6 (–0.053 to 0.035) | 0.21 | .90 |
Notes: The cases and controls used for the RPS6KA1 study were a subset described previously (5). We captured 24 of 24 alleles at r 2 ≥ .8, ie, we captured 100% of SNPs, and mean of maximum r 2 was .94 for the four tagSNPs. CI = confidence interval; SNP = single-nucleotide polymorphism.