Table 4.
Histopathological changes of rat liver after CCl4 and anise seed extracts and essential oil administration
| Groups | Changes | Centrilobular necrosis | Fatty changes | Inflammatory cells infiltration |
|---|---|---|---|---|
| Control | 0 (0,0) | 0 (1,0) | 0 (0,1) | |
| + CCl4 | 1 (1,1) a | 1 (2,1) a | 1 (2,2) a | |
| + NE (100 mg/kg) | 0 (1,0) b | 1 (0,1) b | 0 (1,0) b | |
| +HE (200 mg/kg) | 1 (1,0) | 1 (2,2) | 1 (1,1) | |
| + E (100 mg/kg) | 1 (1,1) | 1 (2,1) | 1 (1,1) | |
0=absent; 1=mild; 2=moderate; and 3=severe histopathological changes
Data are presented as median and quartiles for five random pictures per group
a Indicates significant difference as compared with control group (P<0.05)
b Indicates significant difference as compared with CCl4-treated group (P<0.05)
E: Essential oil, HE: Hydroalcoholic extract, NE: n-hexane extract