TABLE 1.

Effects of GlyR deletion on the LORR produced by ethanol and other sedative drugs

Drugs were injected intraperitoneally. Values represent mean ± S.E.M.

Drugs	LORR	Glra2		Glra3
		(+/Y)	(−/Y)	(+/+)	(−/−)
dose	min
Ethanol (3.6 g/kg)	Duration	45.5 ± 2.64	43.4 ± 3.06	59.0 ± 0.78	59.9 ± 3.48
		n = 10	n = 10	n = 6	n = 6
	Latency	1.92 ± 0.08	2.11 ± 0.20	1.86 ± 0.13	2.20 ± 2.21
Flurazepam (225 mg/kg)	Duration	99.1 ± 4.82	96.0 ± 1.48	96.1 ± 6.85	94.5 ± 7.24
		n = 4	n = 5	n = 4	n = 5
	Latency	4.82 ± 0.09	4.66 ± 0.17	9.35 ± 1.12	8.66 ± 1.25
Ketamine (175 mg/kg)	Duration	39.1 ± 0.90	38.3 ± 0.53	40.9 ± 0.63	39.8 ± 0.64
		n = 5	n = 5	n = 4	n = 4
	Latency	1.34 ± 0.14	1.37 ± 0.11	0.87 ± 0.13	0.87 ± 0.21