Fig. 8.

Lamotrigine normalized pilocarpine (Pilo; 10 μM)-induced Ca²⁺ response in 9 DIV HN cultures. (A) Representative traces showing the actions of LTG on pilocarpine-induced Ca²⁺ dynamics. (B) Expanded traces showing LTG actions on pilocarpine-induced Ca²⁺ responses. (C) LTG reversed the pilocarpine-induced prolongation of SCO lifetime. Each data point represents at least three replicates, and the experiments were repeated twice in independent cultures with similar results. **P < 0.01, pilocarpine versus Veh (vehicle); ^##P < 0.01, pilocarpine+LTG versus pilocarpine.