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Time course for the onset of wash-resistant signaling. HEK293 cells expressing 5-HT2C receptors were treated with 25 nM Erg or 10 μM Cab for the indicated times, followed by drug washout. IP production was measured in serum-free culture media without drugs for 60 minutes. Data are expressed as the percentage of maximal IP production achievable with that drug, with basal IP levels subtracted out. Data represent the mean ± S.E.M. from three experiments.
