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(A). Chemical structure of ESI-09 and its analogs based on the core structure of 2-(5-(tert-butyl)isoxazol-3-yl)-2-oxo-N-phenyl- acetohydrazonoyl cyanide. (B) Dose-dependent competition of cAMP and ESI-09 analogs with 8-NBD-cAMP in binding to EPAC2.
