Table 1. Potency of ESI-09 analogs in competing with 8-NBD-cAMP binding to EPAC2.

Compound	IC50 (µM)
cAMP	32.0 ± 5.9
ESI-09	9.0 ± 1.2
HJC0693	28.3 ± 4.0
HJC0694	26.5 ± 4.1
HJC0695	59.8 ± 9.4
HJC0696	7.3 ± 1.2
HJC0726	1.9 ± 0.3
HJC0750	35.6 ± 7.8
HJC0777	3.0 ± 0.6