Table 3. Differential expression of cytokines comparing high NLR and low NLR groups in exploratory (cohort 1) and validation (cohort 2) cohorts.
|
Exploratory cohort (cohort 1) (N=39) |
Validation cohort (cohort 2) (N=166) |
|||||
|---|---|---|---|---|---|---|
|
Median |
Median |
|||||
| Cytokinesa | Low NLR | High NLR | P-value | Low NLR | High NLR | P-value |
| IL-6 | 8.730 | 12.33 | 0.016 | 11.10 | 21.07 | <0.001 |
| IL-8 | 3.060 | 10.95 | 0.021 | 19.44 | 50.00 | <0.001 |
| IL-2Rα | 179.7 | 235.5 | 0.006 | 183.8 | 268.2 | <0.001 |
| HGF | 417.4 | 651.1 | 0.012 | 229.3 | 354.9 | <0.001 |
| M-CSF | 22.68 | 39.85 | 0.003 | 6.380 | 8.100 | 0.035 |
| VEGF-A | 32.73 | 118.5 | 0.015 | 13.51 | 29.01 | 0.004 |
| IL-12 | 390.5 | 440.1 | 0.498 | 8.820 | 18.72 | 0.010 |
| MIP-1β | 36.54 | 34.31 | 0.855 | 59.76 | 77.43 | <0.001 |
| GROα | 104.7 | 132.3 | 0.222 | 2.030 | 49.85 | <0.001 |
| IL-18 | 62.57 | 72.54 | 0.970 | 82.04 | 110.8 | <0.001 |
| MIF | 398.3 | 662.1 | 0.054 | 169.2 | 235.3 | 0.018 |
| SCGF-β | 25 911 | 27 526 | 0.130 | 10 184 | 16 270 | <0.001 |
| TRAIL | 206.0 | 231.6 | 0.637 | 55.21 | 26.64 | <0.001 |
| Amphiregulin | NE |
3.120 | 189.4 | <0.001 | ||
| EGF | NE |
11.47 | 28.24 | 0.016 | ||
| Epiregulin | NE |
4.770 | 24.40 | 0.038 | ||
| HB-EGF | NE |
87.05 | 203.3 | 0.001 | ||
| Tenascin | NE |
1118 | 1602 | 0.001 | ||
| TGF-α | NE |
0.030 | 4.090 | 0.025 | ||
| ICAM-1 | NE | 124 061 | 189 463 | 0.001 | ||
Abbreviations: EGF=epidermal growth factor; GROα=chemokine (C-X-C motif) ligand 1 (CXCL1); HB-EGF=heparin-binding EGF-like growth factor; HGF=hepatocyte growth factor; ICAM-1=intercellular adhesion molecule-1; IL=interleukin; M-CSF=macrophage-colony stimulating factor; MIF=macrophage migration inhibitory factor; MIP-1β=macrophage inflammatory protein-1β NE=not evaluated; NLR=neutrophil-lymphocyte ratio; SCGF-β=stem cell growth factor-β TGF-α=transforming growth factor-α TRAIL=TNF-related apoptosis-inducing ligand; VEGF-A=vascular epidermal growth factor A.
a
Cytokines are measured in pg ml−1.