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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Biomarkers. 2014 Jul 2;19(6):471–480. doi: 10.3109/1354750X.2014.937361

Table 5.

Associations between OBS and biomarkers (continuous) in the SRSH population using linear regression.

Biomarker Method 1c Method 2d Method 3e
Regression coefficient (95%CI) p Value Regression coefficient (95%CI) p Value Regression coefficient (95%CI) p Value
All participantsa
 Ln (FIP) −0.02915 (−0.04998, −0.00832) <0.01 −0.02598 (−0.04241, −0.00955) <0.01 -0.02579 (-0.04383, -0.00775) <0.01
 Ln (mtDNA) 0.00349 (−0.01524, 0.02223) 0.71 −0.01675 (−0.02896, −0.00455) 0.40 -0.00644 (-0.02145, 0.00857) 0.40
 Ln (FOP) 0.03122 (0.00898, 0.04828) <0.01 0.02641 (0.01412, 0.03869) <0.01 0.03259 (0.01530, 0.04988) <0.01
NHWb
 Ln (FIP) −0.04358 (−0.07497, −0.01219) <0.01 −0.02932 (−0.05559, −0.00305) 0.04 −0.03042 (−0.05864, −0.00220) 0.04
 Ln (mtDNA) 0.01495 (−0.03571, 0.06562) 0.52 −0.01497 (−0.03920, 0.00926) 0.16 −0.01776 (−0.04288, 0.00735) 0.16
 Ln (FOP) 0.02954 (0.00994, 0.04913) <0.01 0.02578 (0.01052, 0.04104) <0.01 0.02907 (0.01005, 0.04808) <0.01
AAb
 Ln (FIP) −0.01638 (−0.06143, 0.02867) 0.46 −0.03722 (−0.07258, −0.00185) 0.47 −0.01390 (−0.05191, 0.02410) 0.47
 Ln (mtDNA) 0.00215 (−0.10550, 0.10979) 0.96 −0.02759 (−0.05451, −0.00067) 0.04 −0.00536 (−0.04482, 0.03410) 0.79
 Ln (FOP) 0.06208 (0.00143, 0.12273) 0.05 0.03059 (0.00295, 0.05824) 0.03 0.06502 (0.00668, 0.12336) <0.01
WAb
 Ln (FIP) 0.01071 (−0.02990, 0.05133) 0.59 0.00220 (−0.02536, 0.02976) 0.85 0.01657 (−0.03659, 0.03016) 0.85
 Ln (mtDNA) −0.00083 (−0.02326, 0.02160) 0.94 −0.00614 (−0.02446, 0.01218) 0.95 −0.00059 (−0.02055, 0.01937) 0.95
 Ln (FOP) 0.00109 (−0.05284, 0.05501) 0.97 0.01383 (−0.02247, 0.05013) 0.45 0.00729 (−0.04646, 0.06105) 0.78

OBS = oxidative balance score; FOP = florescent oxidation products; FIP = F2-isoprostanes; mtDNA = mitochondrial DNA copy number; NHW = Non-Hispanic White; AA = African American; WA = West African, CI = confidence interval.

a

Adjusted for age, sex, race/ethnicity, and BMI.

b

Adjusted for age, sex, and BMI.

c

Method 1 - analytical population only includes participants with complete information on OBS components.

d

Method 2 - analytical population includes participants with missing values for OBS components. Imputed values for missing OBS components were randomly assigned.

e

Method 3 - analytical population includes participants with missing values for OBS components. Imputed values for missing OBS components were the observed median values for the same age, gender, and race/ethnicity category.