Table 3.
Long-term immune reactivity of protected animal, RAt-9.
| NAb reactivity: | |||
|---|---|---|---|
| time post-SHIV-1157ipd3N4 challenge |
SHIV-1157ip | SHIV- 1157ipd3N4 |
|
| 18 mos | 90 | <10 | |
| 24 mos | 110 | <10 | |
| Cellular immune reactivity1: | ||||
|---|---|---|---|---|
| SIV Gag-specific ELISPOTS: | 5,853 ± 910/106 PBMC | |||
| Intracellular staining: | SIV Gag peptide stimulation | |||
| % IFN-γ | %TNF-α | % IL-2 | ||
| CD3+CD8+ | 0.38 | 1.14 | 0.58 | |
| CD3+CD4+ | 0.92 | 2.61 | 2.61 | |
1
Cellular immune reactivity was tested 41 months post-SHIV-1157ipd3N4 challenge. Intracellular staining values show the percentage of each gated population showing expression of the indicated cytokine. Background values (no stimulation) have been subtracted.