Table 1. Association between FoxM1, FoxO3a expression and clinicopathological parameters in breast cancer patients.

Clinicopathological features	No.	FoxM1 (Immunoreactive score)	P value (t-test)	FoxO3a (Immunoreactive score)	P value (t-test)
Histologic grade
Grade 1	40	4.70 ± 3.252	0.172†	3.70 ± 2.319	0.016*
Grade 2	96	5.19 ± 3.089		3.80 ± 2.569
Grade 3	100	4.35 ± 3.089		4.77 ± 2.853
Primary tumor size
< 2 cm	113	4.12 ± 3.049	0.003	4.02 ± 2.731	0.379
≥ 2 cm	123	5.33 ± 3.096		4.32 ± 2.638
Lymph node metastasis
Absent	131	4.08 ± 3.312	< 0.001	4.08 ± 2.640	0.528
Present	105	5.58 ± 2.670		4.30 ± 2.741
AJCC stage
Stage I	82	3.60 ± 3.181	< 0.001†	3.94 ± 2.659	0.766†
Stage II	97	5.33 ± 3.009		4.36 ± 2.739
Stage III	57	5.53 ± 2.788		4.20 ± 2.652
Lymphovascular invasion
Absent	124	4.06 ± 3.342	< 0.001	4.04 ± 2.604	0.393
Present	112	5.51 ± 2.688		4.33 ± 2.770
Perineural invasion
Absent	184	4.80 ± 3.217	0.597	4.20 ± 2.793	0.909
Present	51	4.53 ± 2.880		4.16 ± 2.257
ER expression
Negative	112	4.85 ± 3.208	0.648	3.91 ± 2.745	0.157
Positive	124	4.66 ± 3.063		4.40 ± 2.617
HER2 amplification
Absent	188	4.79 ± 3.053	0.878	4.02 ± 2.641	0.059
Present	48	4.71 ± 3.396		4.83 ± 2.801

^*One-way ANOVA.