Table 2. Univariate and multivariate Cox regression analyses of various prognostic parameters for survival in breast cancer patients.
| Parameters | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Disease free survival | ||||||
| Histologic grade (G1 vs. G2 & 3) | 0.707 | 0.410-1.219 | 0.212 | |||
| Primary tumor size (≤ 2 cm vs. > 2 cm) | 2.954 | 1.684-5.182 | < 0.001 | 1.841 | 1.009-3.358 | 0.047 |
| Lymph node metastasis (absent vs. present) | 4.344 | 2.421-7.793 | < 0.001 | 2.755 | 1.339-5.668 | 0.006 |
| AJCC stage (I & II vs. III & IV) | 4.081 | 2.458-6.774 | < 0.001 | 3.851 | 1.158-4.047 | 0.016 |
| Lymphovascular invasion (absent vs. present) | 3.885 | 2.135-7.066 | < 0.001 | NS | ||
| FoxM1 expression (low vs. high) | 1.383 | 0.781-2.451 | 0.266 | |||
| FoxO3a expression (low vs. high) | 1.127 | 0.611-2.078 | 0.702 | |||
| ER expression (negative vs. positive) | 0.773 | 0.466-1.283 | 0.302 | |||
| HER2 amplification (absent vs. present) | 1.035 | 0.538-1.991 | 0.917 | |||
| Overall survival | ||||||
| Histologic grade (G1 vs. G2 & 3) | 0.983 | 0.477-2.027 | 0.964 | |||
| Primary tumor size (≤ 2 cm vs. > 2 cm) | 3.253 | 1.454-7.278 | 0.004 | NS | ||
| Lymph node metastasis (absent vs. present) | 3.320 | 1.528-7.210 | 0.002 | NS | ||
| AJCC stage (I & II vs. III & IV) | 3.851 | 1.903-7.792 | < 0.001 | 3.851 | 1.903-7.792 | < 0.001 |
| Lymphovascular invasion (absent vs. present) | 2.722 | 1.253-5.912 | 0.011 | NS | ||
| FoxM1 expression (low vs. high) | 1.932 | 0.801-4.664 | 0.143 | |||
| FoxO3a expression (low vs. high) | 0.862 | 0.347-2.138 | 0.748 | |||
| ER expression (negative vs. positive) | 0.465 | 0.226-0.958 | 0.038 | NS | ||
| HER2 amplification (absent vs. present) | 1.117 | 0.458-2.725 | 0.807 | |||
HR, harzard ratio; CI, confidence interval; NS, not significant.