Table 3. Univariate and multivariate analyses of various prognostic parameters for survival in ER-positive breast cancer patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Disease free survival | ||||||
| Histologic grade (G1 vs. G2 & 3) | 0.097 | 0.013-0.709 | 0.022 | NS | ||
| Primary tumor size (≤ 2 cm vs. > 2 cm) | 2.979 | 1.425-6.226 | 0.004 | NS | ||
| Lymph node metastasis (absent vs. present) | 4.855 | 2.091-11.27 | < 0.001 | 3.676 | 1.412-9.572 | 0.008 |
| AJCC stage (I & II vs. III & IV) | 4.672 | 2.309-9.454 | < 0.001 | NS | ||
| Lymphovascular invasion (absent vs. present) | 4.798 | 1.968-11.70 | 0.001 | NS | ||
| FoxM1 expression (low vs. high) | 2.694 | 1.035-7.014 | 0.042 | NS | ||
| FoxO3a expression (low vs. high) | 1.261 | 0.511-3.111 | 0.614 | |||
| HER2 amplification (absent vs. present) | 1.312 | 0.949-1.814 | 0.101 | |||
| Overall survival | ||||||
| Histologic grade (G1 vs. G2 & 3) | 0.281 | 0.036-2.176 | 0.224 | |||
| Primary tumor size (≤ 2 cm vs. > 2 cm) | 3.195 | 0.960-10.64 | 0.058 | |||
| Lymph node metastasis (absent vs. present) | 3.873 | 1.047-14.32 | 0.042 | NS | ||
| AJCC stage (I & II vs. III & IV) | 4.041 | 1.301-12.55 | 0.016 | 4.041 | 1.301-12.550 | 0.016 |
| Lymphovascular invasion (absent vs. present) | 3.127 | 0.845-11.57 | 0.088 | |||
| FoxM1 expression (low vs. high) | 7.304 | 0.897-59.45 | 0.063 | |||
| FoxO3a expression (low vs. high) | 0.941 | 0.223-3.980 | 0.934 | |||
| HER2 amplification (absent vs. present) | 1.314 | 0.769-2.244 | 0.318 | |||
HR, harzard ratio; CI, confidence interval; NS, not significant.