Fig. 2. Time-dependent changes in skin gross morphology of a mini-pig after treatment with either 50 or 100 Gy of β-irradiation delivered by a ¹⁶⁶Ho skin patch. (A) Two weeks after β-irradiation (50 Gy). (B) Four weeks after irradiation (50 Gy). (C) Eight weeks after irradiation (50 Gy). (D) Fourteen weeks after irradiation (50 Gy). (E) Two weeks after irradiation (100 Gy). (F) Four weeks after irradiation (100 Gy). (G) Eight weeks after irradiation (100 Gy). (H) Fourteen weeks after irradiation (100 Gy). (I) The dose- and time-dependent gross morphological changes of pig skin after application of a ¹⁶⁶Ho skin patch (50 or 100 Gy). Data are expressed as the mean ± SEM. ^*p < 0.05 vs. the sham controls. Scale bar = 1 cm.