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. 2015 Mar 20;7:32. doi: 10.3389/fnagi.2015.00032

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Copyright © 2015 Murillo-Cuesta, Rodríguez-de la Rosa, Contreras, Celaya, Camarero, Rivera and Varela-Nieto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution of hearing after administration of TGF-β1 inhibitors before noise exposure. (A) Evolution of ABR thresholds (mean ± SEM, in dB SPL) in MF1 mice (n = 6 per group) treated with TGF-β1 inhibitors P17 or P144 at 2.5 mg/kg/24 h/15 days, or saline, and exposed to 100 dB VS noise overnight. Statistically significant differences (ANOVA with Bonferroni post hoc test, p ≤ 0.05) were found between P17 (triangle, *p ≤ 0.05) or P144 (square, #p ≤ 0.05, ##p ≤ 0.01,) and the saline group (circles), 1 and 7 days after exposure. (B) The evolution of peak I latency (mean ± SEM, in ms) in P17 (black bars), P144 (gray bars) and saline (white bars) treated mice showed a similar pattern. A statistically significant increase in peak I latency was observed 1 day after noise exposure in the three groups (paired T test compared to post-treatment values, **p ≤ 0.01).