Skip to main content
. 2015 Mar 20;7:32. doi: 10.3389/fnagi.2015.00032

Figure 5.

Figure 5

Protein levels after noise exposure and treatment with TGF-β1 inhibitor. Time course of phospo-p38/p38α, phospho-SMAD2/SMAD2/3, NOX-4/MAPK and MnSOD/β-actin ratios relative (%) to non-exposed mice (white bars), in cochlear samples of noise-exposed (VS2–20 at 110 dB SPL) CBA mice (n = 3 mice for each determination) and treated with TGF-β1 inhibitor P144 at 10 mg/kg/24 h/15 days (black) or saline (gray). Representative blots are shown. Data are shown as mean ± SD. Statistically significant differences were found in p-p38, NOX4 and MnSOD levels after noise exposure compared to values in non-exposed mice (paired T test, *p ≤ 0.05; **p ≤ 0.01). Noise induced statistically significant increases in p-p38, p-SMAD2 and MnSOD ratios compared to non-exposed mice (paired T test, *p ≤ 0.05; **p ≤ 0.01). Treatment with P144 showed significantly lower levels of p-p38α and p-SMAD2 and higher levels of MnSOD compared to saline-treated mice (paired T test, #p ≤ 0.05; ##p ≤ 0.01).