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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2014 Jun 9;78:193–201. doi: 10.1101/sqb.2013.78.020081

Figure 3. Homeostatic inhibition maintained by homing cues for Tregs.

Figure 3

Antigen presenting cells exposed to environmental cues such as retinoic acid (small intestine) and TGFβ (large intestine) migrate to the mesenteric lymph nodes where they activate naïve T cells. Endothelial cell expression of the corresponding ligands for homing receptors (CCL25 in the small intestine; CCL28 and unknown GPR15 ligand in the large intestine) enable activated T cells expressing unique homing receptors (CCR9 for the small intestine; CCR10 and GPR15 for the large intestine) to home back to the site of antigen capture.