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. 2015 Apr 1;22(10):819–831. doi: 10.1089/ars.2014.6017

FIG. 2.

FIG. 2.

Nrf1(b)-KO mice exhibit severe hyperinsulinemia. (A) Blood glucose levels under nonfasting (left panel) and fasting (right panel) conditions. n=9–13 for nonfasting measurements; n=20–27 for fasting measurements. Animal age is 11–17 weeks. (B) Fasting plasma insulin levels. n=9–20. Animal age is 11–17 weeks. (C) Fasting plasma insulin levels in age-matched males. n=5–17. Animal age is 11–12 weeks. *p<0.05 versus Nrf1(b)-WT. (D) Fasting plasma glucagon levels in males. n=8–34. Animal age is 11–17 weeks. *p<0.05 versus Nrf1(b)-WT; #p<0.05 versus RIP-Cre; &p<0.05 versus Nrf1(b)-HET. KO, knockout.