FIG. 1.
Joint response to middle carpal joint intraarticular administration of rAAV2-IGF-I, rAAV5-IGF-I, or DPBS. (A) Percent change in joint circumference was measured after vector injection to quantify joint swelling. (B) Lameness grading was performed serially after injection, using the AAEP scoring system.24 (C and D) Synovial fluid total protein concentration and total nucleated cell count, respectively, were quantified to evaluate general inflammatory changes in synovial fluid composition. Graphs illustrate mean values±SEM averaged from four horses. *p<0.05.