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. 2015 Feb 13;290(12):7362–7368. doi: 10.1074/jbc.C115.637918

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — PDLIM2 reconstitution blocks KSHV-mediated transformation of HUVECs and suppresses the growth and tumorigenicity of KSHV-associated PEL cells both in vitro and in vivo. A, upper panels, IB assays showing exogenous PDLIM2 expression in HUVEC stable cell lines. Lower panels, morphology assays indicating that PDLIM2 reconstitution suppresses KSHV-mediated transformation of HUVECs. Scale bar: 100 μm. B, upper panels, IB assays showing reconstituted PDLIM2 in PEL cell lines. Lower panels, cell counting assays showing decreased growth rate of PEL cells reconstituted with PDLIM2. C, soft agar assays showing decreased anchorage-independent growth of PEL cells reconstituted with PDLIM2. D, SCID mouse xenograft assays showing decreased tumor formation ability of PEL cells reconstituted with PDLIM2. E, SCID mouse xenograft assays showing decreased ascites and tumor formation of PEL cells reconstituted with PDLIM2. Data are mean ± S.D. *, p < 0.05; **, p < 0.01.