TABLE 1.

ACTH analogs in ligand binding and signaling

ACTH analog peptides	hMC2R
	IC50	EC50
	nm
ACTH(1–17)	5.5 ± 1.0	5.5 ± 1.0
ACTH(1–24)	3.9 ± 1.2	1.3 ± 0.2
ACTH(1–39)	4.6 ± 1.2	3.2 ± 0.5
[d-Phe7]ACTH(1–17)	—a	—
[d-Phe7]ACTH(1–24)	28 ± 3.4	39 ± 11
[d-Nal(2′)7]ACTH(1–17)	26 ± 2.5	58 ± 4.5
[d-Nal(2′)7]ACTH(1–24)	23 ± 3.3	38 ± 5.5

^a —, no binding and signaling.