FIGURE 1.

NaMN adenylyltransferase NadD catalyzes the first indispensable step in the biogenesis and homeostasis of NAD(P) redox cofactors in mycobacteria. The NAD cofactor pool requires constant replenishing due to its degradative utilization by non-metabolic enzymes such as DNA ligase (LigA) and protein lysine deacetylase (CobB). Note that NadD substrate, NaMN, is a unique checkpoint intermediate shared by all, de novo, salvage, and recycling, pathways (shown by dotted arrows with enzyme names denoted as respective gene products).