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Design of Trp substitution mutations in the PD-associated mutants of α-Syn. Amino acid sequences of the PD-associated mutants E46K, A53T, and A30P of α-Syn and their designed Trp-substituted mutants are shown. The PD mutations are shown in red, and the Trp substitutions are shown in blue. The rectangular boxes indicate the Trp mutation site in the three regions, N terminus (V3W), middle NAC (V71W), and C terminus (A124W and A140W), of the PD-associated mutants.
