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Model of how phosphorylation and mutually exclusive association with securin or Cdk1-cyclin B1 determine the fate of separase across the cell cycle. The minimal module of separase control (shown in boldface) relies only on the positive and negative effects of Cdk1-cyclin B1 (Cyc.B1) on separase to maintain faithful chromosome segregation in the absence of securin. pSeparase, phosphorylated separase; APC/C, anaphase-promoting complex/cyclosome.
