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. 2015 Feb 12;15(2):4229–4241. doi: 10.3390/s150204229

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Intracellular concentration of the activated regulator at the center of a bacterial colony as a function of the colony size. The full curves represent cooperative ligand binding, and the dashed curves represent independent binding. When r_m > K_s, the hysteresis leading to a robust switch is present for cooperative ligand binding, as well as for independent binding. With cooperative binding, the switch is well defined at moderately lower r_m values than obtained with non-cooperative binding. Adapted from [11]—published by The Royal Society of Chemistry.