Figure 5.

Generation of CD8 T cell response vs. protection. CD8 T cells are generated following exposure to parasite antigens through natural infection. Depending on the availability and affinity of antigens CD8 T cell clonotypes would have access to MHC/p complexes. Initially MHC/p in excess or with high affinity would preferentially induce the specific T cells. During subsequent antigen exposures other antigens would come into picture while response to previously generated CD8 T cells will be boosted. Gradually over time the desired repertoire of T cells with required frequencies would be generated helping protect the host from the incoming infection.