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. 2015 Mar 20;6:116. doi: 10.3389/fimmu.2015.00116

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Copyright © 2015 Basu, Sanchez and Casiano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of DFS70/LEDGFp75 and its autoantibodies. (A) Staining pattern of human autoantibodies to DFS70/LEDGFp75 in HEp-2 slides visualized by indirect immunofluorescence (IIF) microscopy. Arrows point to bright staining in condensed metaphase chromosomes. (B) Immunoblot showing reactivity of a human serum containing anti-DFS70/LEDGFp75 autoantibodies against total protein lysates from PC3 prostate cancer cells. A prominent band of approximately 75 kDa was observed with the serum. Immunoreactivity was detected by enhanced chemiluminescence. (C) Diagram depicting the main structural domains and motifs of DFS70/LEDGFp75 with their proposed functions.