Frontocortical cytokine levels are decreased following methamphetamine treatment. Bar graphs represent concentration levels of each cytokine in 100 μg of total protein +SEM. (a) Significant reduction in frontocortical interleukin (IL)-1β (t(9)=2.2341, p<0.05), IL-6 (t(9)=2.308, p<0.05), IL-10 (t(9)=2.432, p<0.05), and tumor necrosis factor alpha (TNFα) (t(9)=2.454, p<0.05) in the methamphetamine group was found. (b) The increases in cytokine levels in amygdala were not significant, and (c) there were no between-group differences in striatal cytokine levels. *p<0.05.