FIG. 3.

Effect of AMPCP (100, 150, 200 mg/kg), EHNA (75, 100, 150 mg/kg), dipyridamole (5, 10, 20 mg/kg), and NBTI (5, 10, 15 mg/kg) on locomotor activity and progression of the PTZ-induced seizures in zebrafish. (A, C, E, G) Locomotor activity was measured as distance traveled during the 30 min following drug pretreatments. (B, D, F, H) Latency to the first behavioral manifestation of each seizure stage (I, II, and III) during PTZ exposure. The data are expressed as the mean±SD from 12, 8, 8, and 12 animals for AMPCP, EHNA, dipyridamole, and NBTI, respectively, and were analyzed by one-way ANOVA followed by Dunnett's post hoc test. The symbols represent statistical difference when compared with the respective vehicle control group (DMSO 3% and Saline). *p<0.05, **p<0.005, ***p<0.0005.