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. 2015 Mar 20;9:93. doi: 10.3389/fnins.2015.00093

Figure 1.

Figure 1

AZT reduces MASC population expansion. (A) Primary MASCs exposed to a single 7 day pulse of 30 μM AZT show a significant decrease in population expansion over the first and second passages (1stP, 2ndP). By the third passage (3rdP), treated cells recover and slightly exceed the expansion of untreated cells, although this difference was not maintained, and control and treated groups equilibrated at later passages (not shown). (B) Naïve 1stP, 2ndP, and 3rdP MASCs exposed to a single 7 day pulse of 30 μM AZT show that “older” cells (increased in vitro passage) are substantially more vulnerable to the suppressive effects of AZT than “younger” cells. Unpaired t-test of significance; N = 3 for all groups; *p < 0.05; **p < 0.01; ***p < 0.001. Error bars represent standard deviation.