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. 2015 Mar 20;6:96. doi: 10.3389/fgene.2015.00096

FIGURE 3.

FIGURE 3

Pathways involved in homologous recombination repair of DSBs. (A,B) Analysis of the data from genome-wide siRNA screens. Data were adapted from published studies (Słabicki et al., 2010, A) and (Adamson et al., 2012, B). In these studies HR efficiency was assessed using DR-GFP assay in HeLa cells (left) and in DR-U2OS cells (right). Relative HR scores in Z-score (left panel) and ‘Relative HR score’ (right panel) are indicated for genes with an established role in HR: BRCA1, BRCA2, TP53BP1, NUP153, and RAD51. (C) Gene-Set Enrichment Analysis (GSEA) was performed on the data presented in (A,B). Four pathway databases were used for enrichment analysis: KEGG, Biocarta, Reactome, and GeneOntology. Results of the GSEA on the dataset by Słabicki et al. (2010) are represented in light gray, and results on the dataset by Adamson et al. (2012) are represented in dark gray. Red dashed line indicates 95% confidence interval.