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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Mol Pharmacol. 2003 May;63(5):1021–1031. doi: 10.1124/mol.63.5.1021

Fig. 6.

Fig. 6

Rhodopsin-based molecular model of the A3AR, showing the previously defined docking mode of the A3-selective agonist Cl-IB-MECA (colored according to atom type) and a putative allosteric binding site for VUF5455 (orange) on TM 7. Shown are selected residues near the allosteric modulator and residues F182 and N274, which were found to be important for the allosteric action of VUF5455. The secondary structure of each TM is displayed by ribbon using different colors, which indicate TMs 1, 2, 3, 4, 5, 6, and 7 with red, orange, yellow, green, cyan, blue, and purple color, respectively. The coordinates of this A3AR model are available as from the Protein Data Bank ftp site under the name pdblo74.ent.Z. See http://www.rcsb.org/pdb/pdb_news2002.html#models_removal2 for more information.