Table 2. Number of biopsies necessary for accurate molecular diagnosis of the listed genes in respect to the various bronchoscopical biopsy techniques.
| 21 g -NA |
19 g - NA |
NA |
14 g - NA |
TBB |
Cryo |
|
|---|---|---|---|---|---|---|
| Cell block | ||||||
| Number of biopsies | 4 | 4 | 4 | 2-3 | 4-5 | 4-5 |
| Kras mutation | + | + | + | ++ | + | ++ |
| EGFR mutation | + | + | ++ | ++ | ++ | ++ |
| TS (IHC/PCR) | + | (+) | + | ++ | ++ | ++ |
| ERCC1 (IHC/ PCR) | - | (+) | + | ++ | + | ++ |
| RRM1 PCR | - | (+) | w+ | ++ | + | ++ |
| EML4-ALK | + | + | + | ++ | ++ | ++ |
TBB: Transbronchial biopsy; NA: Needle aspiration; Cryo: Cryobiopsy; IHC: Immunhistochemistry; PCR: Polymerase chain reaction - not suitable; (+): Limited; +: Sufficient; ++: Good