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Ligand stimulation of ERK and PI3K signaling in BRAFV600E melanomas. In untreated melanomas, there is low signalability. However, hours after the ERK pathway is inhibited, the transduction of the signal is markedly potentiated (restored signalability). The induction of signalability could be blocked with the addition of an HER kinase inhibitor, such as neratinib (2).
