Table 1. Ongoing trials on Met inhibitors.

Molecule	Targets	Type	Phase	Monotherapy or combination	Drug associated	Patient populations
Tivantinib	c-Met	TKI	I	Combination	Topotecan	SCLC
			II	Combination	Erlotinib	EGFR pos NSLC
			II	Combination	Erlotinib	KRAS pos    NSCLC
AMG 337	c-Met	TKI	I	Monotherapy	-	Solid tumors
Cabozantinib	c-Met, VEGFR2, RET, Kit, AXL, FLT3	TKI	II	Monotherapy	-	Solid tumors
			II	Monotherapy	-	KIF5B/RET NSCLC
			II	Combination	Erlotinib	EGFR neg NSCLC
Foretinib	c-Met, VEGFR, PDGFRb, Tie-2, RON, Kit, FLT3	TKI	I-II	Combination	Erlotinib	NSCLC
Golvatinib	c-Met, VEGFR	TKI	I	Monotherapy	-	Solid tumors
MGCD265	c-Met, VEGFR, RON, Tie2	TKI	I-II	Combination	Erlotinib/ Docetaxel	NSCLC
Onartuzumab	c-Met	MoAb	II rand	Combination	CBDCA-Pacl	Squamous NSCLC
			III	Combination	Erlotinib	Met positive NSCLC
			II rand	Combination	Platinum + Pem; Platinum + Pacl + Bev	Non-squamous NSCLC
Rilotumumab	HGF	MoAb	I-II	Combination	Erlotinib	NSCLC

CBDCA, carboplatin; Pacl, paclitaxel; Pem, pemetrexed; Bev, bevacizumab; rand, randomised; SCLC, small cell lung cancer; NSCLC, non-small cell lung cancer; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; EGFR, epidermal growth factor; KIF5B/RET, kinesin family member 5B/ret proto-oncogene; Met, met proto-oncogene; TKI, tyrosine kinase inhibitor; MoAb, monoclonal antibody