Table 4. Grade >3 toxicity with EGFR-TKIs.

	Gefitinib					Erlotinib			Afatinib
	NEJSG 002 (10) n=114	IPASS (4) n=607	First-SIGNAL (8) n=159	WJTOG3405 (9) n=87		OPTIMAL (11) n=83	EURTAC (5) n=84		LUX-3 (12) n=229
Rash	71.0 [5.3]	66.2 [3.1]	72.3 [1.3]	74 [2]		73.5 [2.4]	11 [13.0]		37 [16.2]
Diarrhea	34.2 [0.9]	46.6 [3.8]	NR	47[1]		25.3 [1.2]	4 [5.0]		33 [14.4]
Fatigue	10.5 [2.6]	NR	28.3 [0.6]	34 [2]		4.8 [0]	5 [6.0]		3 [1.3]
Anorexia	NR	21.9 [1.5]	44.7 [0]	NR		NR	0 [0]		7 [3.1]
Stomatitis	9.6 [0]	17.0 [0.2]	NR	19 [0]		13.3 [1.2]	NR		20 [8.7]
Paronychia	NR	13.5 [0.3]	NR	28 [1]		3.6 [0]	NR		26 [11.4]
Vomiting	6.1 [0.9]	12.9 [0.2]	NR	NR		NR	NR		7 [3.1]