| Inclusion criteria |
| -Unresectable stage Non-Small Cell Lung Cancer (NSCLC) |
| -ATS/ERS Predicted values |
| Forced Expiratory Volume in 1 sec (FEV1) no less than ≤50% |
| Forced Vital Capacity (FVC) no less than ≤50% |
| Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) no less than ≤50% |
| -Tumor diameter no larger than ≥5 cm |
| -Unpreviously treated NSCLC |
| -Saturation oxygenation upon rest ≤90% and exercise oxygene saturation ≥80% |
| -Karnofsky performance status ≥80 |
| -Adequate laboratory values in order to receive chemotherapy |
| Exclusion criteria |
| -Known collagen disease (interstitial lung disease, systematic lupus erythromatosis, rheumatoid arthritis e.t.c) |
| -Alnagesic treatment with opioids prior to treatment initiation |
| -Recent surgery |
| -Active respiratory infection |
| -Previous immunotherapy, or concurrently included in another protocol |
| -Unstable or serious concurrent medical condition (e.g., recent myocardial infarction and superior vena cava syndrome) |
| -Previous radiotherapy sessions to the thorax |
