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editorial
. 2014 Aug;3(4):238–241. doi: 10.3978/j.issn.2218-6751.2013.12.06

Figure 2.

Figure 2

Endothelial Dll4 induced Notch1 activation in cancer cells. (A) It was proposed by Ding et al. that Dll4 on endothelial cells (ECs) activated Notch1 signaling in NSCLC cells and cancer cell proliferated (18); (B) Dll4-overexpressed ECs induced Notch1 signaling and PTEN expression in NSCLC cells, and suppression of cancer cell growth was observed; (C) when co-cultured with the ECs lacking Dll4 expression, increased NSCLC proliferation was observed in vitro and in a xenograft mouse model.