Table 1. Anti-tumor strategies targeting Dll4/Notch signaling.

Name	Mechanisms used to block Dll4-Notch signaling	Cancer cell type
Anti-Dll4 antibodies	Anti-Dll4 antibody	Colon cancer, lung cancer
Anti-hDLL4	Anti-Dll4 antibody	Colon cancer
Dll4 vaccine	DNA vacination	Mammary carcinoma
Dll4-Fc	Soluble Dll4-Fc	Lung cancer
D4ECD-Fc	Soluble Dll4-Fc	Human glioblastoma
sDll4-Fc	Soluble Dll4-Fc	Colon cancer, sarcoma
Notch1 decoy	Notch-Fc decoys	Neuroblastoma
Compound X	Γ-secretase inhibitors	Renal cell carcinoma